Nature Neuroscience

Nature Neuroscience, Published online: 11 September 2026; doi:10.1038/s41593-026-02415-9 Frontal cortical tau pathology in aging humans is associated with reduced slow-wave travel during sleep. This reduced propagation is associated with poorer overnight memory retention, supporting a link between slow-wave travel and age-related memory function.

Nature Neuroscience, Published online: 10 September 2026; doi:10.1038/s41593-026-02430-w Using a combined approach of monkey electrophysiology, artificial neural networks and human psychophysics, Xue et al. show that neuronal interference from irrelevant information underlies behavioral errors under task uncertainty.

Nature Neuroscience, Published online: 10 September 2026; doi:10.1038/s41593-026-02429-3 Using experiments and theory, the authors examine how olfactory memories are encoded in the zebrafish olfactory cortex. They find that experience reshapes the internal map of odor space, making relevant information more accessible.

Nature Neuroscience, Published online: 09 September 2026; doi:10.1038/s41593-026-02424-8 The authors develop SORDINO, a silent, sensitive and distortion-free fMRI method. They benchmark the technique against conventional approaches, reveal its functional contrast mechanisms and use it to perform brain-wide imaging of skilled motor behavior and social interaction in mice.

Nature Neuroscience, Published online: 09 September 2026; doi:10.1038/s41593-026-02401-1 Mapping brain-wide networks in behaving animals remains a formidable challenge. MacKinnon and colleagues introduce SORDINO-fMRI, a silent, motion-resistant framework that captures global dynamics during complex behaviors in mice while enabling artifact-free simultaneous network-level recordings with cellular …

Nature Neuroscience, Published online: 09 September 2026; doi:10.1038/s41593-026-02432-8 van der Valk et al. mapped the cell types that build the human inner ear during early development, identifying a molecular signal that instructs cell specification and using it to improve organoid models of this organ of hearing and balance.

Nature Neuroscience, Published online: 08 September 2026; doi:10.1038/s41593-026-02418-6 Although Alzheimer’s disease (AD) is a disease of the brain, we demonstrate that it disrupts myeloid cell production in the bone marrow via a type I interferon signal, preventing protective monocyte-derived macrophages from reaching the brain. Blocking this signal in the 5xFAD mouse model of amyloidosis resto…

Nature Neuroscience, Published online: 08 September 2026; doi:10.1038/s41593-026-02428-4 Intestinal CD4+ T cells migrate to the dura and brain following gut infection with bacteria or parasites, establishing a long-lived memory population capable of proliferation and cytokine production following rechallenge with bloodborne pathogens.

Nature Neuroscience, Published online: 08 September 2026; doi:10.1038/s41593-026-02417-7 Alzheimer’s disease progression involves reduced bone marrow production of myeloid cells due to type I interferon signaling, which hampers the homing of protective immune cells to the affected brain. In a mouse model, inhibiting this pathway restored immune cell recruitment and halted disease progression.

Nature Neuroscience, Published online: 07 September 2026; doi:10.1038/s41593-026-02447-1 Implanted brain–computer interfaces hold great promise for restoring communication and other functions and for revealing new aspects of human brain physiology. Yet as the number of implantations in humans expands, ethical clarity must keep pace with technical ambition. We propose that this should involve dist…

Nature Neuroscience, Published online: 04 September 2026; doi:10.1038/s41593-026-02442-6 Why some skills are easier to learn than others remains a central question in neuroscience. Busch and colleagues demonstrate that the intrinsic geometry of human brain activity shapes learning, thereby facilitating adaptation that remains within existing neural manifolds while limiting learning beyond them.

Nature Neuroscience, Published online: 04 September 2026; doi:10.1038/s41593-026-02463-1 Author Correction: Choroid plexus apocrine secretion shapes CSF proteome during mouse brain development

Nature Neuroscience, Published online: 04 September 2026; doi:10.1038/s41593-026-02434-6 This study argues that neuromodulation should harness the brain’s natural compensatory adaptations, rather than solely restore healthy-like dynamics, providing a framework for improving cognition in psychiatric and aging populations.

Nature Neuroscience, Published online: 03 September 2026; doi:10.1038/s41593-026-02427-5 The authors identify peripheral dendritic cell priming of T cells as a key driver of brain inflammation and neurodegeneration in a mouse model of tauopathy, providing new insights into immune mechanisms contributing to tau-dependent neurodegeneration.

Nature Neuroscience, Published online: 03 September 2026; doi:10.1038/s41593-026-02409-7 The authors use recurrent neural networks to predict how structured prior experience shapes neural dynamics as mice learn flexible timing strategies during complex context-dependent behavior.

Nature Neuroscience, Published online: 02 September 2026; doi:10.1038/s41593-026-02421-x This study shows that addictive drugs hijack mitochondrial Ca2+-dependent bioenergetics in reward circuits to drive pathological dopamine release, identifying mitochondrial calcium uniporter as a metabolic gatekeeper.

Nature Neuroscience, Published online: 02 September 2026; doi:10.1038/s41593-026-02414-w This study shows that glutamate concentration at synapses can dynamically reshape how synaptic AMPA receptors pass current and calcium. This reveals a rapid way that synapses tune communication in the brain.

Nature Neuroscience, Published online: 01 September 2026; doi:10.1038/s41593-026-02439-1 A new direction for neural networks

Nature Neuroscience, Published online: 01 September 2026; doi:10.1038/s41593-026-02440-8 Plasma biomarkers for ALS

Nature Neuroscience, Published online: 01 September 2026; doi:10.1038/s41593-026-02441-7 Stressing out astrocyte cilia