A multi-omics case–control study identifying oropharyngeal microbiome–metabolite patterns that characterize secondary bacterial pneumonia among influenza patients
Peng Huang
Secondary bacterial pneumonia is a severe complication of influenza;howeve the biological determinants that distinguish progression from uncomplicated infection remain poorly understood. We investigated the oropharyngeal microbiome and plasma metabolome as potential discriminators of pneumonia development. In this study, we report a cross-sectional case–control study conducted during the 2022–2023 influenza season to identify and internally validate a microbiome-metabolite profile that character