Kupffer cell calibration of T cell responses via VSIG4–CD5 interaction promotes tumor evasion
Zhutian Zeng
Nature Immunology, Published online: 29 April 2026; doi:10.1038/s41590-026-02510-w VSIG4 is a co-inhibitory receptor expressed by Kupffer cells. Here, the authors identify a direct binding interaction between VSIG4 and T cell CD5 that can calibrate CD8+ T cell responses to liver metastasis. They also design an anti-VSIG4 nanobody to enhance immune checkpoint blockade treatment of mice.