The host immune response to Mycobacterium tuberculosis determining protection or disease progression
Anne O’Garra
Nature Immunology, Published online: 18 May 2026; doi:10.1038/s41590-026-02529-z O’Garra and colleagues discuss the evolving spectrum of M. tuberculosis infection outcomes and TB disease, how the host immune response determines and unfolds across this spectrum and how the natural diversity of M. tuberculosis contributes to this complexity.