Suppression of astrocyte BMP signaling improves molecular signatures and functional deficits in a fragile X syndrome mouse model
Nicola J. Allen
Nature Communications, Published online: 23 April 2026; doi:10.1038/s41467-026-71919-6 Deng et al. use genetics, transcriptomics, and proteomics to find that inhibiting the BMP signaling pathway in astrocytes improves some symptoms of fragile X syndrome in the Fmr1 KO mouse model. Mechanisms underlying the improvement are identified.