A glycan-based adjuvant expands the breadth and duration of protection of mRNA-based vaccines
Ivan Zanoni
Nature Immunology, Published online: 22 May 2026; doi:10.1038/s41590-026-02517-3 Jena, Qu et al. show that mannadjuvant, a formulation of fungal mannan and aluminum hydroxide, increases the magnitude, durability and breadth of the response elicited by mRNA-based vaccines against SARS-CoV-2 variants in mice and non-human primates.