Dynamic recruitment of CaMKII into SHANK3 phase-separated condensates tunes postsynaptic density remodeling during long-term potentiation
Shuwen Chang
Nature Communications, Published online: 20 April 2026; doi:10.1038/s41467-026-72234-w In this study, the authors find that SHANK3’s large intrinsically disordered region mediates phase separation to support postsynaptic density remodeling during long-term potentiation, providing an insight into how autism spectrum disorder-linked SHANK3 mutations disrupt synaptic plasticity.