Off-label practice is often needed in ophthalmology, due to the limited number of drugs approved to treat several ocular diseases and to manage challenging ocular surgeries. The aim was to analyze the off-label drug prescriptions issued from January 2014 to December 2024 at the Department of Ophthalmology of the University Hospital of Catania (Italy). 233 off-label prescriptions, comprising 13 drugs, were delivered to treat 225 patients affected by ocular disorders. Results of the present study