FNR-like unit interacts with C-terminal related residues trigger nNOS reductase domain conformational flexibility change
Nan Wang
IntroductionThe reductase domain of neuronal nitric oxide synthase (nNOS) is essential for nitric oxide (NO) production in the mammalian nervous system. Excessive NO contributes to neurological disorders, including ischemic stroke, highlighting the need to better understand the structural dynamics of this domain. The FNR- like unit within the reductase domain stabilizes the cofactors NADP(H), FAD, and FMN, which are critical for NO synthesis. However, the dynamic interactions between these cofac