Sleep duration, depressive symptoms, and postoperative delirium: a mediation analysis
Yu-Bo Xie
PurposeThe mechanism linking postoperative sleep duration to postoperative delirium (POD) remains unclear. This study examined the potential indirect pathway involving depressive symptoms (assessed via the PHQ-9) in the association between postoperative sleep duration and POD.MethodsWe included 500 patients aged ≥ 65 years undergoing unilateral total hip or knee arthroplasty under general anesthesia. The associative pathways among sleep duration, depressive symptoms, and POD were assessed using