BCAT1 inhibits crotonate-related epigenetic modulation of metabolic genes in tumor-associated macrophages to counter immunosuppression
Lianxin Liu
Nature Communications, Published online: 11 May 2026; doi:10.1038/s41467-026-72814-w Immunosuppressive tumor-associated macrophages (TAM) contribute to resistance to immune checkpoint blockade. Here, the authors propose BCAT1 to inhibit crotonate-mediated epigenetic reprogramming of tumor-associated macrophages, with BCAT1 loss promoting immune escape in hepatocellular carcinoma mouse models.