A membrane-modulated chemoenzymatic dynamic kinetic resolution for the synthesis of chiral phthalidyl esters
Guohua Liu
Nature Communications, Published online: 02 May 2026; doi:10.1038/s41467-026-72684-2 The development of chemoenzymatic dynamic kinetic resolution has long been constrained by principal limitations, which need precise synchronization of racemization and resolution steps for rate matching. Here, the authors introduce a membrane-modulated strategy that circumvents the mandatory requirement for strict rate matching.