Nature Microbiology, Published online: 10 June 2026; doi:10.1038/s41564-026-02381-9 Higher lipid intake in mice causes damage to goblet cells with depletion of Akkermansia muciniphila and increase in Clostridium scindens abundance, which produces secondary bile acids that activate pathways driving increased intestinal fat absorption.
Dietary fat alters goblet cell function and microbial bile acid metabolism to promote intestinal lipid absorption in mice
Cen Xie