Pseudomonas aeruginosa, a Gram-negative pathogen, poses a great risk to immunocompromised populations due to its multidrug resistance. This pathogen is prevalent in hospital environments and has been detected in spaceflight-related settings, including the International Space Station. Astronauts, who often experience immune dysregulation, are particularly vulnerable to infections from P. aeruginosa. Given this, the pathogen has been classified as an urgent threat, underscoring the need for novel