In search of the perfect conditions for Suzuki–Miyaura cross-couplings

Marco Ortiz
Developments in Suzuki–Miyaura (SM) couplings are discussed from a historical standpoint as they are especially valued C–C bond-forming reactions in the fine chemicals industry today. However, discussion from the increasingly important standpoint of sustainability is also considered when looking for conditions leading to the perfect coupling. Thus, several procedures now exist leading to the desired SM couplings, which reproducibly occur in or on water, rather than in traditional, petroleum-base