Response mechanism of hepatorenal metabolic barrier function to drugs and environmental poisons and intervention strategy of natural products
Che Xu
Liver and kidney, as the core metabolic detoxification organs of human body, rely on specific biofilm barrier and metabolic enzyme system to form metabolic barrier respectively. This metabolic barrier is the key defense line to resist the invasion of drugs and environmental poisons. There are significant differences in the structural function and toxic response mechanism of the metabolic barrier between the liver and kidney. This review explains the core composition and physiological function of