Short-term sleep benefits versus long-term pulmonary risks: an updated meta-analysis of benzodiazepine receptor positive allosteric modulators in COPD patients with comorbid insomnia

ObjectiveGiven the high prevalence and clinical significance of insomnia in COPD patients, and the ongoing controversy surrounding benzodiazepine receptor positive allosteric modulators (PAMs) therapy, this study systematically evaluates the dual-temporal (short- and long-term) safety profile of PAMs through simultaneous assessment of therapeutic benefits and multidimensional risks in COPD-insomnia comorbidity.MethodsA systematic review and meta-analysis was conducted following the PRISMA guidel