Discovery of novel quinazoline-sulfonamide derivatives with promising antidiabetic activity
Abdelsattar M. Omar
IntroductionFive new quinazoline-sulfonamide hybrids 4a (MZ-13), 4b (MZ-20), 4c (MZ-25), 4d (MZ-26), and 6a (MZ-29) were designed, synthesized, and investigated for their in vitro and in vivo antidiabetic activities.MethodsThe in vivo screening was conducted in a mouse model of type II diabetes induced by streptozotocin (STZ), using glibenclamide as the positive control. The in vitro model was performed by measuring the activity of these compounds against the PPARγ enzyme. Furthermore, the total