Structural basis for transport and inhibition of nucleotide sugar transport in pathogenic fungi
Simon Newstead
Nature Communications, Published online: 02 May 2026; doi:10.1038/s41467-026-72729-6 Invasive fungal pathogens have become a significant concern in healthcare systems worldwide. Here, authors demonstrate that nanobodies targeting the GDPmannose transporter can arrest fungal cell growth. The structures also reveal the complete transport cycle for an SLC35 nucleotide sugar transporter.