Metal-organic frameworks-mediated reactive oxygen species modulation in the tumor microenvironment of digestive system malignancies: latest advances
Siwen Liu
Digestive system malignancies, such as gastric cancer (GC), colorectal cancer (CRC), and hepatocellular carcinoma (HCC), have become a major global challenge in cancer therapy. These tumors are characterized by high morbidity, strong metastatic potential, and significant chemoresistance, thus posing a severe threat to human digestive health. One of the primary mechanisms underlying the malignant progression of tumors and the development of drug-resistant phenotypes is the imbalance of redox home