Integrative systems biology identifies SIRT1 as a senescence-related theranostic target in atherosclerosis and poliumoside as a natural activator
Qiao-Ping Wang
BackgroundCellular senescence contributes to atherosclerotic plaque progression and instability, yet senescence-related diagnostic biomarkers and actionable targets remain incompletely defined.PurposeTo identify senescence-related diagnostic/therapeutic targets in atherosclerosis using integrative systems biology, and to prioritize natural products that modulate the lead target with experimental validation.MethodsTranscriptomic profiles from GSE21545 (126 carotid plaques and 97 paired peripheral