DeepDrugDiscovery identifies blood–brain barrier permeable autophagy enhancers for Alzheimer’s disease
Jia-Hong Lu
Nature Biomedical Engineering, Published online: 24 April 2026; doi:10.1038/s41551-026-01667-x DeepDrugDiscovery is an AI-powered screening platform incorporating ADMET and blood–brain barrier penetrability predictions to successfully identify mTOR-independent autophagy enhancers that can cross the blood–brain barrier for Alzheimer’s disease therapy.