Transcranial temporal interference stimulation of the thalamus in a patient with disorders of consciousness: a case report

Pu Wang
BackgroundProlonged disorders of consciousness (pDoC) are conditions with impaired consciousness lasting over 28 days, including coma, vegetative state/unresponsive wakefulness syndrome (VS/UWS), and minimally conscious state (MCS). Existing treatments offer limited benefit. Although thalamic deep brain stimulation (DBS) has shown potential to improve cognitive and behavioral function, its invasiveness limits clinical use. Transcranial temporal interference stimulation (TIS)—a noninvasive method