A long-read human pangenome initiative for comprehensive interpretation of nuclear-embedded mitochondrial DNA
Yafei Mao
Nature Communications, Published online: 15 May 2026; doi:10.1038/s41467-026-71348-5 NUMTs record mitochondrial‑to‑nuclear DNA transfer, but their diversity is not well defined. Here, the authors create a pangenome‑based NUMT map, revealing hundreds of fixed and polymorphic events, regulatory activity, lineage‑specific dynamics and NUMT‑derived tandem repeats.