Azoxystrobin induces mitochondrial dysfunction and mitochondrial pathway apoptosis by targeting the Prx1 Trp87 and Thr90 sites in oral leukoplakia
Xiaofei Tang
IntroductionOral leukoplakia (OLK) is a prevalent oral potentially malignant disorder with limited treatment options. Our previous research showed that Azoxystrobin (AZOX) induces apoptosis and inhibits mitochondrial complex III activity. Peroxiredoxin 1 (Prx1) plays an important role in OLK progression, and preliminary evidence suggests AZOX may target Prx1 to disrupt mitochondrial function. This study aims to elucidate the precise molecular mechanism by investigating AZOX’s interaction with sp