Potential molecular pathways and therapeutic implications of rapid-acting antidepressants on myelin biology: a scoping review
Marie-Ève Tremblay
BackgroundEmerging evidence indicates that rapid-acting antidepressants (RAADs)—including ketamine and serotonergic psychedelics- may affect myelin homeostasis, aside from producing fast-onset, sustained improvements in several psychiatric disorders.MethodsA systematic search of PubMed (MEDLINE), Web of Science, Europe PMC, Directory of Open Access Journals (DOAJ), and Google Scholar was conducted up to October 2025 for studies examining the effects of RAADs on myelination and oligodendrocyte bi