Optimization of individualized therapy with oral valproic acid in pediatric patients with epilepsy based on factors influencing blood concentrations
Weihong Niu
BackgroundValproic acid (VPA) is widely used in pediatric epilepsy, but its blood concentrations vary considerably among pediatric patients with epilepsy. This study aimed to investigate the factors influencing VPA blood concentrations in this population.MethodsThis study included patients with epilepsy aged 0–18 years who were treated with VPA. Clinical data collected included age, gender, daily dose, biochemical parameters (liver and renal function), and electrolyte levels. VPA blood concentra