Therapeutic effect of Tripterygium hypoglaucum (H. Lév.) Hutch. extract on psoriasis-like skin inflammation correlated with gut microbiota homeostasis in mice
Jianzhou Ye
BackgroundTripterygium hypoglaucum (H. Lév.) Hutch. (THH) exerts anti-inflammatory and immunosuppressive effects against psoriasis. However, the extent to which and the mechanisms by which it ameliorates psoriasis-like dermatitis through modulation of the gut microbiota-metabolite axis remain unclear.MethodsThis study investigated the therapeutic effects and underlying mechanisms of THH in a murine model by employing 16S rRNA gene sequencing, intestinal metabolomic profiling, fecal microbiota tr