Considering biological limitations of lesion network mapping
Maurizio Corbetta
Nature Neuroscience, Published online: 20 May 2026; doi:10.1038/s41593-026-02319-8 Lesion network mapping (LNM), or atrophy network mapping, has become a widely adopted tool for linking focal brain lesions or neurodegenerative brain clusters, respectively, to distributed functional networks associated with cognitive or clinical deficits. Recent insights, however, suggest that LNM primarily captures elementary topological properties of the normative connectome rather than disorder-specific circui