A viral APOBEC3 antagonist distinguishes HHV-6A from HHV-6B
Yasuko Mori
Nature Communications, Published online: 01 May 2026; doi:10.1038/s41467-026-71951-6 Human herpesvirus 6B (HHV-6B) is more pathogenic than closely related HHV-6A. Here the authors show that APOBEC3 enzymes restrict HHV-6A replication, while the U28 protein of HHV-6B counteracts APOBEC3 activity resulting in higher virus replication.