Effects of different mixing techniques on mRNA lipid nanoparticle physicochemistry and biological performance
K. Ristroph
Nature Communications, Published online: 30 April 2026; doi:10.1038/s41467-026-72499-1 Lipid nanoparticle formulation requires a mixing step which can impact performance. Here, the authors report on a study into the differences different mixing techniques have showing that hand pipetting and microfluidic mixers produce different lipid nanoparticles to commercial turbulent flow mixers