Atomic structures of medin and Aβ fibrils reveal polymorphic remodeling in mixed amyloid systems
Joost Schymkowitz
Nature Communications, Published online: 28 April 2026; doi:10.1038/s41467-026-72515-4 Authors solve structures of in vitro Aβ40:medin mixtures to show three fibril populations and association within co-assemblies. Results support two non-exclusive mechanisms: transient interactions redirecting Aβ folding or partial medin incorporation into fibril assembly.