A dihydrofuro[2,3-b] benzofuran derivative alleviates lipopolysaccharide induced acute lung injury via suppressing MAPK signaling
Chengyun Xu
IntroductionRhodomyrtus tomentosa (Ait.) Hassk. (Myrtaceae) has been traditionally used in Southeast Asia to treat inflammation, fever, and respiratory ailments. However, its bioactive components and molecular mechanisms remain unclear. To design novel dihydrofuro [2,3-b]benzofuran derivatives inspired by R. tomentosa constituents and to evaluate their anti-inflammatory activity and mechanism in a lipopolysaccharide (LPS)-induced acute lung injury (ALI) model.MethodsA series of rhodomentosone-li