Nature Immunology, Published online: 18 August 2026; doi:10.1038/s41590-026-02612-5 Microfold cells are known for ferrying gut antigens to immune cells to trigger antibody responses. We identify a second function for microfold cells in Peyer’s patches in establishing a spatial niche that positions group 3 innate lymphoid cells and sustains their production of the protective cytokine interleukin-22.