K2P channels underlie background K+ currents that act as brakes on neuronal excitability. In the somatosensory system, the K2P channels TASK-1 and TASK-3 play a relevant role in cold sensing, mechanosensitivity, and pain. Combining molecular docking and molecular dynamic simulations, patch-clamp recordings of recombinant channels, Ca2+-imaging and patch-clamp analysis in cultured primary somatosensory neurons from trigeminal and dorsal root ganglia, extracellular recording of the nerve endings o