Naringenin inhibited vascular calcification and attenuated senescence-associated changes through the p53/TOP2Aaxis
Rui Yan
BackgroundVascular calcification (VC) is a major cardiovascular complication of chronic kidney disease (CKD). Senescence-associated vascular changes have been increasingly implicated in CKD-related VC. Naringenin, a natural flavonoid with anti-oxidative and anti-inflammatory properties, has shown protective effects in several age-related disorders, but its role and mechanism in CKD-associated VC remain unclear.MethodsHuman vascular specimens, high-Pi-induced vascular smooth muscle cells (VSMCs),