Unlocking biological barriers: nonclinical safety considerations for RNA-based complex biologics
Tae-Won Kim
Nature Reviews Drug Discovery, Published online: 10 April 2026; doi:10.1038/d41573-026-00056-y Bioconjugated oligonucleotides (BCOs) promise to expand the applicability of RNA-based medicines. Here, we present recommendations for nonclinical safety strategies in advancing BCOs into the clinic.