Enzymatic cleavage weaponizes bacterial lipoproteins into immune tripwires
Anirban Banerjee
Nature Immunology, Published online: 25 May 2026; doi:10.1038/s41590-026-02532-4 An amino acid metabolic enzyme transforms bacterial lipoproteins into disulfide-linked lipid structures that activate the non-canonical inflammasome, redefining cytosolic innate immune sensing as a process shaped by host metabolic remodeling.