A transgene-free, human peri-gastrulation embryo model presents trilaminar embryonic disc-, amnion- and yolk sac-like structures

Jianping Fu
Nature Cell Biology, Published online: 17 April 2026; doi:10.1038/s41556-026-01930-y Sun et al. present a stem cell-derived embryo model recapitulating certain aspects of human peri-gastrulation, including the formation of trilaminar disc-, amnion- and yolk sac-like structures.