Nature Communications, Published online: 17 August 2026; doi:10.1038/s41467-026-76553-w Diabetic wounds are among the most difficult chronic injuries to treat due to their severely dysregulated microenvironment. Photothermal therapy (PTT) has emerged as a promising approach for combating drug-resistant infections and improving lowerlimb perfusion in diabetic patients. However, conventional PTT relies mainly on externally applied laser power, offering little control over photothermal temperature. Here, the authors report a thermal-feedback modality-switchable (TFMS) hydrogel that enables stage-adaptive temperature regulation following repair phases of infected diabetic wounds.