Atomic structure and plasticity of the CTX-MthK complex investigated by cryo-EM, NMR, and MD simulations

Nature Communications, Published online: 20 August 2026; doi:10.1038/s41467-026-76925-2 Cryo-EM, NMR, and MD simulations reveal how charybdotoxin (CTX) binds to the MthK potassium channel, identifying key residues that stabilize toxin binding and block potassium ion conduction