Multiscale zonation-resolved modeling of dose-dependent determinants of acetaminophen-induced liver injury
Nicolas R. Gallo
IntroductionDrug-induced liver injury (DILI) is a major cause of morbidity and mortality and has an important impact on drug attrition. Recent guidelines from the FDA and previous research encourage the development of virtual twin in silico modeling as a solution to reduce DILI impact.MethodsIn this study, we used our virtual, scalable model of the human liver lobule coupled with an acetaminophen (APAP) metabolic injury model to expand the mechanistic understanding of metabolic zonation paramete