GLP-1 agonist liraglutide decreases operant methamphetamine intake in rats under conditions of short- but not extended-access to the drug
Jana Ruda-Kucerova
ObjectiveGlucagon-like peptide-1 (GLP-1) receptor agonists have emerged as a therapeutic strategy for reducing drug craving and intake. However, their efficacy in methamphetamine use disorder remains unexplored. This study assessed the effects of repeated liraglutide treatment on methamphetamine intravenous self-administration in rats.MethodsMale Wistar rats were trained to self-administer methamphetamine in either short- (1.5-h) or extended- (6-h) access sessions. Once a stable level of drug in