Structural basis for double-stranded DNA cytosine deamination by BaDTF3 and its application in mitochondrial genome editing
Hideki Aihara
Nature Communications, Published online: 05 May 2026; doi:10.1038/s41467-026-72730-z Bacterial DNA deaminase toxins are valuable tools in genome engineering. Here, authors reveal the mechanism of cytosine deamination in double-stranded DNA by BaDTF3/DddB, which is sequence context-nonselective and potentially useful for mitochondrial base editing.