Constructing gene co-functional and co-regulatory networks from public transcriptomes using condition-specific ensemble co-expression
Marek Mutwil
Nature Communications, Published online: 30 April 2026; doi:10.1038/s41467-026-72380-1 Gene co-expression networks reveal co-regulatory and co-functional gene relationships. Here, the authors introduce an ensemble method that combines unsupervised data partitioning with multi-metric co-expression scoring and demonstrates superior performance across public RNA-seq datasets of multiple species.