SLC33A1-mediated glutathione transport regulates ER redox balance and function

Nature Cell Biology, Published online: 01 May 2026; doi:10.1038/s41556-026-01929-5 We developed a rapid endoplasmic reticulum (ER) immunoprecipitation strategy to isolate ER fractions and, by using it, identified SLC33A1 as an ER transporter that exports oxidized glutathione. This finding provides insight into how the ER sets redox balance and provides a framework to define how ER metabolism is controlled and coupled to ER function in physiology and disease.