Mechanisms and functions of large extracellular vesicle biogenesis
Ivan K. H. Poon
Nature Cell Biology, Published online: 15 May 2026; doi:10.1038/s41556-026-01940-w This Review presents the formation of large extracellular vesicle (L-EV) subsets, highlighting that their contents and physiological relevance, for example, in intercellular communication, are driven by the different mechanisms underlying their biogenesis.