Targeting PIP5K ameliorates hepatic cancer by inhibiting PI3K/AKT and the autophagy mechanism and enhancing ROS-mediated apoptosis
V. G. M. Naidu
IntroductionHepatic cancer cells regulate reactive oxygen species (ROS) and lipid kinases to promote proliferation and survival. The role of phosphatidylinositol-4-phosphate-5-kinase (PIP5K) in modulating the autophagy–Nrf2 antioxidant pathway remains unclear. In this study, we investigated the impact of PIP5K on the ROS-dependent autophagy–Nrf2 axis using specific isoform inhibitors (PIP5K1A: ISA-201IB; PIP5K1B: IITZ01) and further identified NG-TZ-17 and NG-TZ-20, which are analogs of IITZ01,