The residues of heavy metals, pesticides and mycotoxins in 42 types of traditional Chinese medicine formula granules (TCMFGs) were determined by inductively coupled plasma mass spectrometry (ICP-MS), high-performance liquid chromatography tandem mass spectrometry (HPLC-MS) and gas chromatography tandem mass spectrometry (GC-MS). The results showed that the detection rate of seven types of heavy metals was 100%. Among the 143 types of pesticides, 78 were detected, with an average detection rate o