In silico discovery of nanobody binders to a G-protein coupled receptor using AlphaFold-Multimer
Katherine J. Susa
Nature Communications, Published online: 23 April 2026; doi:10.1038/s41467-026-72093-5 Antibody discovery often requires major experimental effort. Here, authors report a virtual screen using AlphaFold-Multimer that identified nanobody binders to MRGPRX2, a therapeutic target for itch, demonstrating fully in silico antibody discovery.